White Fang is the titular character and a novel by American author Jack London. First serialized in Outing magazine, it was published in 1906. The story takes place in Yukon Territory, Canada, during the Klondike Gold Rush at the end of the 19th-century, and details a wild wolfdog's journey to domestication. White Fang is a companion novel (and a thematic mirror) to London's best-known work, The Call of the Wild, which is about a kidnapped, domesticated dog embracing his wild ancestry to survive and thrive in the wild.

Much of the novel is written from the view-point of his canine character, enabling London to explore how animals view their world and how they view humans. White Fang examines the violent world of wild animals and the equally violent world of humans. The book also explores complex themes including morality and redemption.

The story begins before the three-quarters wolf-dog hybrid is born, with two men and their sled dog team on a journey to deliver a coffin to a remote town named Fort McGurry in the higher area of the Yukon Territory, Canada. The men, Bill and Henry, are stalked by a large pack of starving wolves over the course of several days. Finally, after all of their dogs and Bill have been eaten, four more teams find Henry trying to escape from the wolves; the wolf pack scatters when they hear the large group of people coming. The story then follows the pack, which has been robbed of its last prey. When the pack finally manages to bring down a moose, the famine is ended; they eventually split up, and the story now follows a she-wolf and her mate, One Eye. The she-wolf gives birth to a litter of five cubs by the Mackenzie River, and all but one die from hunger. One Eye is killed by a lynx while trying to rob its den for food for the she-wolf and her cub; his mate later discovers his remains near the lynx's den. The surviving cub and the she-wolf are left to fend for themselves. Shortly after the she-wolf manages to successfully kill all the lynx kittens, prompting the lynx to track her down and a vicious fight breaks out. The she-wolf eventually kills the lynx but suffers severe injury, the lynx carcass is devoured over a period of seven days.

The cub comes across five Native Americans one day, and the she-wolf comes to his rescue. One man, Grey Beaver, recognizes the she-wolf as Kiche, his brother's wolfdog, who left during a famine. Grey Beaver's brother is dead, so he takes Kiche and her cub, christening the cub White Fang. White Fang has a harsh life in the Indian camp; the current puppy pack, seeing him as a wolf, immediately attack him. He is saved by the Indians, but the pups never accept him, and the leader Lip-lip singles him out for persecution. White Fang grows to become a savage, morose, solitary, and deadly fighter, "the enemy of his kind."

"In order to face the constant danger of hurt and even of destruction, his predatory and protective faculties were unduly developed. He became quicker of movement than the other dogs, swifter of foot, craftier, deadlier, more lithe, more lean with ironlike muscle and sinew, more enduring, more cruel, more ferocious, and more intelligent. He had to become all these things, else he would not have held his own nor survived the hostile environment in which he found himself."

When White Fang is five years old, he is taken to Fort Yukon so that Grey Beaver can trade with the gold-hunters. There, he is bought with several bottles of whiskey by a dog-fighter, Beauty Smith, who gets Grey Beaver addicted to alcohol. White Fang defeats all opponents, including several wolves and a lynx, until a bulldog is brought in to fight him. The bulldog manages to get a grip on the skin and fur of White Fang's neck, and slowly and surely begins to throttle him. White Fang nearly suffocates, but is rescued when a rich, young gold hunter, Weedon Scott, happens by and stops the fight.

Scott attempts to tame White Fang and after a long patient effort he succeeds. When Scott attempts to return to California alone, White Fang pursues him, and Scott decides to take the dog with him back home. In Sierra Vista, White Fang must adjust to the laws of the estate. At the end of the book, a murderous criminal, Jim Hall, tries to kill Weedon Scott's father, Judge Scott, for sentencing him to prison, not knowing that Hall was "railroaded". White Fang kills Hall and is nearly killed himself, but survives. As a result, the women of Scott's estate name him "The Blessed Wolf", and the story ends with White Fang relaxing in the sun with the puppies he had fathered with the sheep-dog Collie.